Sebaceous carcinoma of the forehead: Case report

 

A GIANT PERINEAL NEVUS LIPOMATOSUS SUPERFICIALIS: CASE REPORT

European Medical, Health and Pharmaceutical Journal

             Central Bohemia University

 

 

A GIANT PERINEAL NEVUS LIPOMATOSUS SUPERFICIALIS: CASE REPORT

 

Funda Tamer, Mehmet Eren Yuksel

Abstract

Nevus lipomatosus superficialis is a rare hamartomatous malformation which is composed of ectopic adipocytes in the dermis. It was first reported in 1921 by Hoffmann and Zurhelle. Two clinical forms of nevus lipomatosus superficialis have been described: classical (multiple) and solitary. Classical form of nevus lipomatosus superficialis is usually found on pelvic girdle, trunk, buttocks and thighs as soft, skin colored papules or nodules. It is usually present at birth or it appears in the first two decades of life. The solitary form of lipomatosus superficialis appears as a solitary papule or nodule on the back, scalp and arms of the patients with late onset. The lesions are usually asymptomatic, however some patients may complain about pain and itching. Malignant transformation of nevus lipomatosis superficialis has not been reported yet. Therefore, surgical intervention is only necessary for the patients who have cosmetic concerns. Recurrence after surgical removal is very rare. Perineum is an uncommon localization for nevus lipomatosus superficialis. Hereby, we report a 55-year-old Caucasian female with a 6x5,5x4 cm mass in the perineal region. The patient had cosmetic concerns, therefore she wanted the lesion to be removed surgically. The lesion was surgically removed. The histopathological evaluation of the specimen revealed nevus lipomatosus superficialis. A solitary type of giant nevus lipomatosus superficialis in the perineal region of a patient over the age of 50 is a very rare condition. Even rarely seen, nevus lipomatosus superficialis should be kept in mind in the differential diagnosis of perineal masses.

 

Keywords

Nevus lipomatosus superficialis, Perineum, Surgical excision

 

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References

Ekmekçi, T. R., Köşlü, A., & Sakız, D. (2003). Dev nevus lipomatozus süperfisiyalis olgusu. Turkderm-Arch of Turk Dermatol Venereol, 38, 140-142.
Uncu, S., Bahadır, S., Yaylı, S., Alpay, K., Aykanat D., & Çobanoğlu, Ü. (2005). Nevus lipomatozis süperfisiyalis: Olgu sunumu. Türkiye Klinikleri J Dermatol, 15, 31-33.
Das, D., Das, A., Bandyopadhyay, A., & Kumar, D. (2015). Huge nevus lipomatosus cutaneous superficialis on back: An unusual presentation. Indian J Dermatol, 60(3), 296-297.
Avhad, G., & Jerajani, H. (2013). Nevus lipomatosus cutaneous superficialis. Indian Dermatol Online J, 4(4), 376-377.
Ekmekçi, R., Köşlü, A., Özeren, M., & Ayabakan, Ö. (2005). Ayak tabanı yerleşimli bir nevus lipomatozus süperfisiyalis vakası. İstanbul Tıp Dergisi, 3, 29-30.
Goucha, S., Khaled, A., Zéglaoui, F., Rammeh, S., Zermani, R., & Fazaa B. (2011). Nevus lipomatosus cutaneous superficialis: Report of eight cases. Dermatol Ther (Heidelb), 1(2), 25-30.
Yap, F. B. B. (2009). Nevus lipomatosus superficialis. Singapore Med J, 50(5), e161-e162.
Dhamija, A., Meherda, A., D'Souza, P., & Meena, R. S. (2012). Nevus lipomatosus cutaneous superficialis: An unusual presentation. Indian Dermatol Online J, 3(3), 196-198.
Kim, Y. J., Choi, J. H., Kim, H., Nam, S. H., & Choi, Y. W. (2012). Recurrence of Nevus Lipomatosus Cutaneous Superficialis after CO(2) Laser Treatment. Arch Plast Surg, 39(6), 671-673.
Patil, S. B., Narchal, S., Paricharak, M., & More, S. (2014). Nevus lipomatosus cutaneous superficialis: a rare case report. Iran J Med Sci, 39(3), 304-307.

  DOI: http://dx.doi.org/10.12955/emhpj.v8i2.670

SURGICAL REMOVAL OF THE EPIDERMAL INCLUSION CYSTS WITH SQUEEZE TECHNIQUE: CASE REPORT

European Medical, Health and Pharmaceutical Journal

            Central Bohemia University

 

SURGICAL REMOVAL OF THE EPIDERMAL INCLUSION CYSTS WITH SQUEEZE TECHNIQUE: CASE REPORT

Mehmet Eren Yuksel, Funda Tamer
 

Abstract

Epidermal inclusion cysts are common benign cutaneous cysts which arise from hair follicles. These cysts usually present as asymptomatic, small, smooth, firm, round, slow growing swellings on hair bearing areas such as scalp, face, neck and trunk. Epidermal inclusion cysts are easily diagnosed by their clinical features. However, trichilemmal cyst, dermoid cyst, neurofibroma, hemangioma, lipoma and liposarcoma should also be kept in mind in differential diagnosis of cutaneous cystic lesions. As malignant transformation of epidermal inclusion cysts has been reported, histopathological evaluation of epidermal inclusion cysts is mandatory in order to rule out malignancy. Moreover, giant epidermal inclusion cysts with ulceration, rapid growth, resistance to treatment, recurrence and fistula drainage may have malignant potential. Therefore, epidermal cysts should be surgically removed. There are several different types of surgical techniques to remove cutaneous cysts. A proper surgical technique should facilitate the complete removal of the cyst wall to prevent recurrence. In addition, it should provide minimal scarring and a low wound infection rate. Epidermal inclusion cysts can be easily removed surgically with squeeze technique. In this technique, the cyst is squeezed out through a small incision using both index fingers. Thus, the cyst is not ruptured. The squeeze technique allows the cyst capsule to remain intact. Therefore, the risk of wound infection, recurrence and scar formation is minimized. Hereby, we present a 48-year-old male with multiple epidermal inclusion cysts on the scalp treated surgically with squeeze technique.
 

Keywords

Epidermal inclusion cyst, Squeeze technique, Surgery
 

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References

Antón-Badiola, I., San Miguel-Fraile, P., Peteiro-Cancelo, A., & Ortiz-Rey, J. A. (2010). Squamous cell carcinoma arising on an epidermal inclusion cyst: a case presentation and review of the literature. Actas Dermosifiliogr, 101, 349-53.
Baek, S. O., Kim, S. W., Jung, S. N., Sohn, W. I., & Kwon, H. (2011). Giant epidermal inclusion facial cyst. J Craniofac Surg, 22, 1149-1151.
Durai, R. (2009). Squeeze eversion of small sebaceous cyst-novel technique to prevent rupture during excision. The Internet Journal of Surgery, 20.
Feng, C. J., & Ma, H. (2015). Treatment of epidermal cysts with erbium: YAG laser fenestration: an alternative to surgical intervention. Ann Plast Surg, 74, Suppl 2, S89-92.
Hayes, M. (Ed). (2014). Cysts and lipoma. In: Practical Skin Cancer Surgery, pp 223-232. Marrickville, Elsevier.
Horoz, U., Eryılmaz, T., Özakpınar, H. R., & Tellioğlu, A. T. (2012). Parmak pulpasında epidermal inklüzyon kisti: Geç fark edilen bir olgu. Turk Plast Surg, 20, 43-44.
Hwang, D. Y., Yim, Y. M., Kwon, H., & Jung, S. N. (2008). Multiple huge epidermal inclusion cysts mistaken as neurofibromatosis. J Craniofac Surg, 19, 1683-1686.
Ikizoglu, G., Kaya, T. I., Tursen, U., & Baz, K. (2003). The use of the freer dissector for the removal of trichilemmal cysts. Int J Dermatol, 42, 405-407.
Makhija, M. (2014). Epidermal inclusion cyst embedded in a recurrent benign fibrous histiocytoma. Indian J Dermatol, 59, 490-491.
Mehrabi, D., Leonhardt, J. M., & Brodell, R. T. (2002). Removal of keratinous and pilar cysts with the punch incision technique: analysis of surgical outcomes. Dermatol Surg, 28, 673-677.
Mote, D. G., & Shukla, A. A. (2011). Epidermal inclusion cyst masquerading breast lump. Indian J Surg, 73, 458-459.
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  DOI: http://dx.doi.org/10.12955/emhpj.v8i2.669

Superficial Acral Fibromyxoma: Case Report

Superficial Acral Fibromyxoma: Case Report

 

Funda Tamer* MD, Mehmet Eren Yüksel, MD

 

Address: * Malazgirt State Hospital, Department of Dermatology, Muş, Turkey, Devrek State Hospital, Department of General Surgery, Zonguldak, Turkey

* Corresponding Author: Dr. Funda Tamer, Malazgirt State Hospital, Department of Dermatology, Muş, Turkey. E-mail: fundatmr@yahoo.com

 

Case Report DOI: 10.6003/jtad.1594c7

 

Published:

J Turk Acad Dermatol 2015; 9 (4): 1594c7

This article is available from: http://www.jtad.org/2015/4/jtad1594c7.pdf

 

Keywords: Fibromyxoma, acral, soft tissue, tumor

Abstract

Observation: Superficial acral fibromyxoma is a rare, benign, soft tissue tumor which usually affects the acral sites of hands and feet. It presents clinically as a slow enlarging solitary nodular mass. Hereby, we present a 44-year-old Caucasian female patient with a superficial acral fibromyxoma on the finger. The patient complained of a painful swelling on the middle finger of her right hand. The lesion was surgically removed for further histopathological evaluation. The histopathological evaluation of the specimen revealed fibromyxoma. Although superficial acral fibromyxoma is a rare entity in daily clinical practice, it should be kept in mind in the differential diagnosis of slow growing tumors of the periungual and subungual sites.

Multiple Giant Trichilemmal Cysts of the Head: Case Report

Orijinal Araştırma

Original Investigation

DOI: 10.4274/turkderm.80090

 

 

Psoriasis tedavisinin vücut kompozisyon analizi, metabolik sendrom kriterleri ve psoriatik artrite etkisi

The effect of psoriasis treatment on body composition, components of metabolic syndrome and psoriatic arthritis

Funda Tamer, Mehmet Ali Gürer

Özet

Amaç: Psoriasis etyolojisi net olmayan, immün aracılı mekanizmalarla gelişen, kronik inflamatuvar bir deri hastalığıdır. Kronik inflamasyonun, vasküler ve metabolik bozuklukların gelişmesine neden olarak, psoriasise eşlik eden komorbiditelerin patogenezinde rol oynadığı düşünülmektedir. Özellikle metabolik sendrom komponentlerinden olan obeziteyle psoriasis arasında güçlü bir ilişkiden bahsedilmekte, psoriasis, beden kitle indeksi (BKİ) ve psoriasis tedavisinin karmaşık ilişkisi üzerinde durulmaktadır. Bu çalışmada, metotreksat, siklosporin ve biyolojik ajan olmak üzere sistemik tedavi başlanılan psoriasisli hastalarda, vücut kompozisyon analizlerini, eşlik eden komorbiditeleri ve ilgili laboratuvar bulgularını değerlendirerek, bu tedavi ajanlarının bakılan parametrelere ve komorbiditelere olan etkisini değerlendirmeyi amaçladık.

Gereç ve Yöntem: Çalışmamıza metotreksat, siklosporin ve biyolojik ajan tedavisi alan 79 psoriasisli hasta dahil edildi. Tedavi öncesi ve tedavinin 12. haftasında olmak üzere, hastaların demografik özellikleri, vücut kompozisyon analizleri, eşlik eden komorbiditeler ve bunlarla ilgili laboratuvar bulguları değerlendirilmiş olup, sonuçlar tedavi öncesi ve sonrasında, tedavi grupları arasında karşılaştırıldı.

Bulgular: Biyolojik ajan tedavisi alan hastalarda, eşlik eden komorbidite ve metabolik sendromun daha sık izlendiği görüldü. Biyolojik ajan tedavisiyle vücut yağ oranının arttığı ve yine anti tümör nekrozis faktör alfa (anti-TNF-α) tedavisinin kilo alımına neden olduğu tespit edildi.

Sonuç: Çalışmamızın sonuçları, metabolik sendromun, hastalık süresinin daha uzun ve hastalığın daha şiddetli olması nedeniyle, komorbidite patogenezindeki kronik inflamasyona daha uzun süre ve şiddetli bir şekilde maruz kalan olgularda daha sık izlendiğini düşündürmektedir.

(Türkderm 2015; 49: 41-4)

Anahtar Kelimeler: Psoriasis, komorbidite, vücut kompozisyon analizi

 

Summary

Background and Design: Psoriasis is a chronic inflammatory immune-mediated skin disorder with unknown etiology. Chronic inflammation in psoriasis has a role in the development of metabolic and vascular disorders related with associating comorbidities. Recent studies have suggested a strong association between psoriasis and obesity, which is one of the components of metabolic syndrome, and emphasized the complex relationship of psoriasis treatment with psoriasis and body mass index (BMI). In this study, our aim was to investigate the effect of psoriasis treatment with methotrexate, cyclosporine and biological agents on body composition, comorbidities and associated laboratory findings.

Materials and Methods: Seventy-nine patients treated with methotrexate, cyclosporin and biological agents were included in our study. Demographic characteristics, body composition analysis, psoriasis-related comorbidities and laboratory examinations were evaluated before

and after 12 weeks of systemic treatment.

Results: Comorbidities and metabolic syndrome tended to be more frequent in the anti-tumor necrosis factor alpha (anti-TNF-α)-treated group. Increase in body fat and weight detected in patients receiving biologic drug therapy.

Conclusion: The results of our study showed that patients with severe psoriasis with longer disease duration were more likely to have metabolic syndrome because of severe and long-term inflammation in the pathogenesis of comorbidities. (Turkderm 2015; 49: 41-4)

Key Words: Psoriasis, comorbidity, body composition analysis

 

Kaynaklar

1. Gülekon A, Adışen E: Psoriasis ve komorbiditeler. Türkderm 2008;42 Özel Sayı 2:23-5.

2. Adışen E, Tekin Ö, Gülekon A, Gürer MA: Çocukluk dönemi psoriazisi: 130 olgunun retrospektif değerlendirmesi. Turk J Dermatol 2008;2:43-6.

3. Dauden E, Castaneda S, Suarez C, et al: Clinical practice guideline for an integrated approach to comorbidity in patients with psoriasis. J Eur Acad Dermatol Venereol 2013;27:1387-404.

4. Atakan N, Doğan S: Psoriasis sistemik bir hastalık mıdır? Turk J Dermatol 2012;6:119-22.

5. Gürer MA, Gökalp H: Psoriasis ve obezite. Türkderm 2012;46:3-6.

6. Gelfand JM, Abuabara K: Diet and weight loss as a treatment for psoriasis. Arch Dermatol 2010;146:544-6.

7. Vena GA, Vestita M, Cassano N: Can early treatment with biologicals modify the natural history of comorbidities? Dermatol Ther 2010;23:181-93.

8. Alper S, Akyol M, Atakan N, ve ark: Türkiye psoriasis tedavi kılavuzu 2012. Türkderm 2012;46:1-36.

9. Kim N, Thrash B, Menter A: Comorbidities in psoriasis patients. Semin Cutan Med Surg 2010;29:10-5.

10. Herron MD, Hinckley M, Hoffman MS, et al: Impact of obezity and smoking on psoriasis presentation and management. Arch Dermatol 2005;141:1527-34.

11. Puig L: Obesity and psoriasis: body weight and body mass index influence the response to biological treatment. J Eur Acad Dermatol Venereol 2011;25:1007-11.

12. Aykol C, Mevlitoğlu İ, Özdemir M, Ünal M: Konya yöresindeki psoriasis hastalarının klinik ve sosyodemografik özelliklerinin değerlendirilmesi. Turk J Dermatol 2011;5:71-4.

13. Kimball AB, Guerin A, Tsaneva M, et al: Economic burden of comorbidities in patients with psoriasis is substantial. J Eur Acad Dermatol Venereol 2011;25:157-63.

14. Onsun N, Su Ö, Eriş Z, Davutoğlu M, Cebeci F, Şenocak M: Psoriasisli hastalarda diyabet görülme sıklığına karşılık diyabetli hastalarda psoriasis görülme sıklığı. Turkderm 2010;44:12-4.

15. Gürer MA, Adışen E: Psoriasis, genel bilgiler, epidemiyoloji. Turkderm 2008;42 Özel Sayı 2:15-7.

16. Mrowietz U, Elder JT, Barker J: The importance of disease associations and concomitant therapy for the long-term management of psoriasis patients. Arch Dermatol Res 2006;298:309-19.

17. Erdem HR: Psoriatik artritin klinik özellikleri. Romatizma 2000;15:31-8.

 

A CUTANEOUS HORN MIMICKING POLYDACTYLY: A CASE REPORT

A CUTANEOUS HORN MIMICKING POLYDACTYLY: A CASE REPORT

European Medical, Health and Pharmaceutical Journal

Central Bohemia University

 

Home > Vol 8, No 1 (2015) > Tamer

 

 

 

A CUTANEOUS HORN MIMICKING POLYDACTYLY: A CASE REPORT

 

Funda Tamer, Mehmet Eren Yuksel

Abstract

A cutaneous horn is a general name for cornified material protruding from skin. On the other hand, polydactyly is a common congenital anomaly of the hand and foot which is characterized by extra finger or toe. A cutaneous horn might mimick polydactyly by resembling an extra toe. Hereby, we present a 72-year-old white Caucasian male with an extra toe-like projection on his fourth toe. Initially, polydactyly was suspected, however a cutaneous horn was also considered. The lesion was surgically removed. The histopathological examination of the specimen revealed hyperkeratosis, and thus confirmed the  lesion to be a cutaneous horn. 

 

Keywords

Hyperkeratosis, cutaneous, horn, polydactyly

 

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References

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DOI: http://dx.doi.org/10.12955/emhpj.v8i1.542